Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing Approach

Background: Mutations in the K-Ras gene are among the most frequent genetic alterations in various cancers, and inhibiting RAS signaling has shown promising results in treating solid tumors. However, finding effective drugs that can bind to the RAS protein remains challenging. This drove us to explo...

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Principais autores:	Udhaya Kumar. S, Rinku Polachirakkal Varghese, V. Anu Preethi, C. George Priya Doss, Hatem Zayed
格式:	Artigo
語言:	Inglês
出版:	IMR Press 2023-11-01
叢編:	Frontiers in Bioscience-Landmark
主題:	glide qikprop molecular dynamics simulation e-pharmacophore modeling k-ras
在線閱讀:	https://www.imrpress.com/journal/FBL/28/11/10.31083/j.fbl2811288
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