Analgesic Effect of Boiogito, a Japanese Traditional Kampo Medicine, on Post-Traumatic Knee Osteoarthritis through Inhibition of ERK1/2 Phosphorylation in the Dorsal Horn of the Spinal Cord

Boiogito (BO), a Japanese traditional herbal medicine, has been proven to be clinically effective against knee osteoarthritis (KOA)-associated pain. However, the therapeutic mechanism of BO remains unclear. Thus, we investigated the analgesic mechanism of BO using a rat KOA model. KOA was induced by...

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Autores principales:	Yusuke Kunieda, Takayuki Okumo, Hideshi Ikemoto, Naoki Adachi, Midori Tanaka, Taro Kimura, Kanako Yusa, Koji Kanzaki, Masataka Sunagawa
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	MDPI AG 2021-09-01
Colección:	Applied Sciences
Materias:	osteoarthritis destabilization of the medial meniscus (DMM) kampo boiogito pain ERK
Acceso en línea:	https://www.mdpi.com/2076-3417/11/18/8421
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