Genetic inhibition of CaMKII in dorsal striatal medium spiny neurons reduces functional excitatory synapses and enhances intrinsic excitability.

Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is abundant in striatal medium spiny neurons (MSNs). CaMKII is dynamically regulated by changes in dopamine signaling, as occurs in Parkinson's disease as well as addiction. Although CaMKII has been extensively studied in the hippocampus where i...

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Auteurs principaux:	Jason R Klug, Brian N Mathur, Thomas L Kash, Hui-Dong Wang, Robert T Matthews, A J Robison, Mark E Anderson, Ariel Y Deutch, David M Lovinger, Roger J Colbran, Danny G Winder
Format:	Artigo
Langue:	Inglês
Publié:	Public Library of Science (PLoS) 2012-01-01
Collection:	PLoS ONE
Accès en ligne:	https://doi.org/10.1371/journal.pone.0045323
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