Sodium Phenylbutyrate Attenuates Cisplatin-Induced Acute Kidney Injury Through Inhibition of Pyruvate Dehydrogenase Kinase 4

<b>Background/Objectives:</b> Cisplatin nephrotoxicity is a significant clinical issue, and currently, no approved drug exists to prevent cisplatin-induced acute kidney injury (AKI). This study investigated whether sodium phenylbutyrate (4-PBA), a chemical chaperone, can prevent cisplatin-induced AK...

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Egile Nagusiak:	Chang Joo Oh, Wooyoung Choi, Ha Young Lee, In-Kyu Lee, Min-Ji Kim, Jae-Han Jeon
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	MDPI AG 2024-12-01
Saila:	Biomedicines
Gaiak:	cisplatin nephrotoxicity acute kidney injury sodium phenylbutyrate pyruvate dehydrogenase kinase 4 inflammation apoptosis
Sarrera elektronikoa:	https://www.mdpi.com/2227-9059/12/12/2815
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