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DNA methylation differences within INS, PTPN22 and IL2RA promoters in lymphocyte subsets in children with type 1 diabetes and controls

We elucidated the effect of four known T1D-susceptibility associated single nucleotide polymorphism (SNP) markers in three genes (rs12722495 and rs2104286 in IL2RA, rs689 in INS and rs2476601 in PTPN22) on CpG site methylation of their proximal promoters in different lymphocyte subsets using pyroseq...

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Autors principals: Sirpa Pahkuri, Ilse Ekman, Céline Vandamme, Kirsti Näntö-Salonen, Jorma Toppari, Riitta Veijola, Mikael Knip, Tuure Kinnunen, Jorma Ilonen, Johanna Lempainen
Format: Artigo
Idioma:Inglês
Publicat: Taylor & Francis Group 2023-12-01
Col·lecció:Autoimmunity
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Accés en línia:http://dx.doi.org/10.1080/08916934.2023.2259118
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