Conformational Plasticity of Hepatitis B Core Protein Spikes Promotes Peptide Binding Independent of the Secretion Phenotype

Hepatitis B virus is a major human pathogen, which forms enveloped virus particles. During viral maturation, membrane-bound hepatitis B surface proteins package hepatitis B core protein capsids. This process is intercepted by certain peptides with an “LLGRMKG” motif that binds to the capsids at the...

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Principais autores:	Cihan Makbul, Vladimir Khayenko, Hans Michael Maric, Bettina Böttcher
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2021-04-01
Series:	Microorganisms
Assuntos:	hepatitis B core protein hepatitis B virus peptide inhibitor of envelopment isothermal titration calorimetry electron cryo microscopy low-secretion phenotype mutants
Acceso en liña:	https://www.mdpi.com/2076-2607/9/5/956
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