Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
The Hippo signaling pathway controls tissue growth by regulating the subcellular localization of Yorkie /Yap. Here the authors show that PRP4K, a kinase involved in mRNA splicing, phosphorylates Yki/Yap in the nucleus, which prevents its nuclear accumulation and inhibits Hippo signaling.
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Portfolio
2018-04-01
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| Edice: | Nature Communications |
| On-line přístup: | https://doi.org/10.1038/s41467-018-04090-2 |
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