Redox-dependent plasticity of oxMIF facilitates its interaction with CD74 and therapeutic antibodies
MIF is a ubiquitous protein involved in proinflammatory processes, which undergoes an oxidation-driven conformational change to oxidized (ox)MIF. We demonstrate that hypochlorous acid, produced by neutrophil-released myeloperoxidase (MPO) under inflammatory conditions, effectively oxidizes MIF into...
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| Autori principali: | , , , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Elsevier
2024-09-01
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| Serie: | Redox Biology |
| Soggetti: | |
| Accesso online: | http://www.sciencedirect.com/science/article/pii/S2213231724002428 |
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