Efficacy and safety of tyrosine kinase inhibitor combination therapy for glioblastoma: a meta-analysis with trial sequential analysis of randomized controlled trials

BackgroundTyrosine kinase inhibitors (TKIs) administered as monotherapy have demonstrated limited clinical efficacy in glioblastoma (GBM). This study synthesized evidence from existing randomized controlled trials (RCTs) to evaluate the efficacy and safety of combination treatments incorporating TKI...

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Autores principales:	Pan Wei, Jing Jiang, Ming Xiao, Yuekang Zhang
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2026-04-01
Colección:	Frontiers in Oncology
Materias:	glioblastoma meta-analysis overall survival placebo progression-free survival tyrosine kinase inhibitor
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1796708/full
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