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Structure of avian influenza hemagglutinin in complex with a small molecule entry inhibitor

The binding properties of fusion inhibitor CBS1117 to hemagglutinin by x-ray crystallography, NMR, and mutagenesis give insights into mechanism and guidance for chemical optimization. HA plays a critical role in influenza infection and, thus HA is a potential target for antivirals. Recently, our lab...

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Principais autores: Aleksandar Antanasijevic, Matthew A Durst, Han Cheng, Irina N Gaisina, Jasmine T Perez, Balaji Manicassamy, Lijun Rong, Arnon Lavie, Michael Caffrey
Format: Artigo
Sprog:Inglês
Udgivet: Life Science Alliance LLC 2020-08-01
Serier:Life Science Alliance
Online adgang:https://www.life-science-alliance.org/lookup/doi/10.26508/lsa.202000724
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