HBI: a hierarchical Bayesian interaction model to estimate cell-type-specific methylation quantitative trait loci incorporating priors from cell-sorted bisulfite sequencing data

Abstract Methylation quantitative trait loci (meQTLs) quantify the effects of genetic variants on DNA methylation levels. However, most published studies utilize bulk methylation datasets composed of different cell types and limit our understanding of cell-type-specific methylation regulation. We pr...

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Váldodahkkit:	Youshu Cheng, Biao Cai, Hongyu Li, Xinyu Zhang, Gypsyamber D’Souza, Sadeep Shrestha, Andrew Edmonds, Jacquelyn Meyers, Margaret Fischl, Seble Kassaye, Kathryn Anastos, Mardge Cohen, Bradley E. Aouizerat, Ke Xu, Hongyu Zhao
Materiálatiipa:	Artigo
Giella:	Inglês
Almmustuhtton:	BMC 2024-10-01
Ráidu:	Genome Biology
Fáttát:	Methylation quantitative trait loci Cell-type-specific DNA methylation hierarchical Bayesian interaction model Cell-sorted methylation sequencing data Colocalization
Liŋkkat:	https://doi.org/10.1186/s13059-024-03411-7
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