Hepatitis B virus infection and immunopathogenesis in a humanized mouse model: induction of human-specific liver fibrosis and M2-like macrophages.

The mechanisms of chronic HBV infection and immunopathogenesis are poorly understood due to a lack of a robust small animal model. Here we report the development of a humanized mouse model with both human immune system and human liver cells by reconstituting the immunodeficient A2/NSG (NOD.Cg-Prkdc(...

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Detalhes bibliográficos

Principais autores:	Moses T Bility, Liang Cheng, Zheng Zhang, Yan Luan, Feng Li, Liqun Chi, Liguo Zhang, Zhengkun Tu, Yanhang Gao, Yangxin Fu, Junqi Niu, Fusheng Wang, Lishan Su
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2014-03-01
coleção:	PLoS Pathogens
Acesso em linha:	https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24651854/pdf/?tool=EBI
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