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Biochemical Characterization of MurF from Streptococcus pneumoniae and the Identification of a New MurF Inhibitor Through Ligand-based Virtual Screening

MurF is an essential bacterial enzyme that is involved in the last intracellular stage of peptidoglycan biosynthesis, and therefore it has the potential to be exploited as a target for the development of new antibacterials. Here, we report on the expression, purification and biochemical characteriz...

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Bibliografische Detailangaben
Hauptverfasser: Samo Turk, Martina Hrast, Izidor Sosič, Hélčne Barreteau, Dominique Mengin-Lecreulx, Didier Blanot, Stanislav Gobec
Format: Artigo
Sprache:Inglês
Veröffentlicht: Slovenian Chemical Society 2013-10-01
Schriftenreihe:Acta Chimica Slovenica
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Online-Zugang:https://acsi-journal.eu/index.php/ACSi/article/view/53
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