Sex-Specific Regulation of miR-29b in the Myocardium Under Pressure Overload is Associated with Differential Molecular, Structural and Functional Remodeling Patterns in Mice and Patients with Aortic Stenosis

Pressure overload in patients with aortic stenosis (AS) induces an adverse remodeling of the left ventricle (LV) in a sex-specific manner. We assessed whether a sex-specific miR-29b dysregulation underlies this sex-biased remodeling pattern, as has been described in liver fibrosis. We studied mice w...

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Detalhes bibliográficos

Principais autores:	Raquel García, Ana B. Salido-Medina, Aritz Gil, David Merino, Jenny Gómez, Ana V. Villar, Francisco González-Vílchez, María A. Hurlé, J. Francisco Nistal
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2020-03-01
Colecção:	Cells
Assuntos:	miR-29b aortic stenosis patients pressure overload cardiac remodeling sex differences
Acesso em linha:	https://www.mdpi.com/2073-4409/9/4/833
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