Pharmacological Disruption of Phosphorylated Eukaryotic Initiation Factor-2α/Activating Transcription Factor 4/Indian Hedgehog Protects Intervertebral Disc Degeneration via Reducing the Reactive Oxygen Species and Apoptosis of Nucleus Pulposus Cells

Excessive reactive oxygen species (ROS) and apoptosis in nucleus pulposus (NP) cells accelerate the process of intervertebral disc degeneration (IDD). Here, we integrated pathological samples and in vitro and in vivo framework to investigate the impact of phosphorylation of eukaryotic initiation fac...

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Hlavní autoři:	Junping Bao, Zhanyang Qian, Lei Liu, Xin Hong, Hui Che, Xiaotao Wu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2021-06-01
Edice:	Frontiers in Cell and Developmental Biology
Témata:	intervertebral disc degeneration apoptosis reactive oxygen species eIF2 alpha activating transcription factor 4 Indian hedgehog
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fcell.2021.675486/full
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