Progranulin deficiency in Iba-1+ myeloid cells exacerbates choroidal neovascularization by perturbation of lysosomal function and abnormal inflammation

Abstract Background Age-related macular degeneration (AMD) is the principal cause of permanent blindness among elderly individuals worldwide. Chronic inflammation in the subretinal space is associated with a progression of exudative AMD. Progranulin (PGRN) is a growth factor secreted from myeloid ce...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Kei Takahashi, Shinsuke Nakamura, Wataru Otsu, Masamitsu Shimazawa, Hideaki Hara
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-07-01
coleção:	Journal of Neuroinflammation
Assuntos:	Progranulin Microglia Macrophage Lysosome Inflammation Neovascularization
Acesso em linha:	https://doi.org/10.1186/s12974-021-02203-1
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!