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The Relevance of Pharmacokinetic Biomarkers in Response to Methadone Treatment: A Systematic Review

<b>Background/Objectives</b>: Methadone maintenance treatment (MMT) is widely used in opioid use disorder (OUD). Its efficacy is influenced by its metabolism, primarily mediated by Cytochrome P450 (CYP450) enzymes in the liver. Genetic polymorphisms in CYP450 genes and other factors, such as age, se...

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Автори: Sheila Recarey-Rama, Jesús Gómez-Trigo, Almudena Gil-Rodriguez, Eduardo Dominguez, Inés Sánchez-Martínez, Ángela Riveiro-Recimil, Alba Barral-Raña, Jose de Leon, Ana Rodriguez-Viyuela, Manuel Arrojo, Angel Carracedo, Olalla Maroñas
Формат: Artigo
Мова:Inglês
Опубліковано: MDPI AG 2025-04-01
Серія:Pharmaceuticals
Предмети:
metabolism
genes
methadone
biomarkers
opioid addiction
maintenance therapies
Онлайн доступ:https://www.mdpi.com/1424-8247/18/5/623
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