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Widespread alterations in microRNA biogenesis in human Huntington’s disease putamen

Abstract Altered microRNA (miRNA) expression is a common feature of Huntington’s disease (HD) and could participate in disease onset and progression. However, little is known about the underlying causes of miRNA disruption in HD. We and others have previously shown that mutant Huntingtin binds to Ag...

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Principais autores: Serena Petry, Rémi Keraudren, Behnaz Nateghi, Andréanne Loiselle, Karolina Pircs, Johan Jakobsson, Chantelle Sephton, Mélanie Langlois, Isabelle St-Amour, Sébastien S. Hébert
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2022-07-01
coleção:Acta Neuropathologica Communications
Assuntos:
Huntington’s disease
microRNA
Ago2
Dicer
RNAi
Biogenesis
Acesso em linha:https://doi.org/10.1186/s40478-022-01407-7
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