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Sex-specific role of the 5-HT2A receptor in psilocybin-induced extinction of opioid reward

Abstract Emerging evidence suggests that classical psychedelics may offer therapeutic potential for opioid use disorder (OUD) by alleviating key hallmarks such as altered reward processing and dependence. However, the mechanisms behind these effects remain unclear. Our data demonstrate that a single...

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Hlavní autoři: Alaina M. Jaster, Thomas M. Hadlock, Belle Buzzi, Jessica L. Maltman, Gabriella M. Silva, Somdatta Saha, Eda Koseli, Abby M. Pondelick, Nikita Thakur, Xin Zhang, Gaoshan Li, Sandra Ledesma-Corvi, Karah N. Moore, Hannah R. Peterson, Barbara Fujita, Alexia L. Zylko, Melissa R. Lewis, Justin L. Poklis, Matthew S. Halquist, Jennifer T. Wolstenholme, Dana E. Selley, Peter J. Hamilton, Chang Lu, M. Imad Damaj, Javier González-Maeso
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Portfolio 2025-11-01
Edice:Nature Communications
On-line přístup:https://doi.org/10.1038/s41467-025-64887-w
Tagy: Přidat tag
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