Population pharmacokinetics of high-dose methotrexate in patients with primary central nervous system lymphoma

ObjectiveMethotrexate (MTX) serves as a cornerstone therapy for primary central nervous system lymphoma (PCNSL). However, the considerable intra- and inter-individual variability in its pharmacokinetic and therapeutic efficacy poses significant challenges to clinical application. This study aims to...

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Detalhes bibliográficos

Principais autores:	Shifeng Wei, Sitian Zhang, Dan Wang, Dongjie Zhang, Qian Lu, Jiayi Mo, Zhilin Yang, Leyi Guan, Yingjun He, Zhigang Zhao, Shenghui Mei
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-05-01
coleção:	Frontiers in Pharmacology
Assuntos:	methotrexate primary central nervous system lymphoma population pharmacokinetic model nonlinear mixed-effects modeling estimated glomerular filtration rate blood urea nitrogen
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fphar.2025.1578033/full
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