Single chain variable fragment antibodies directed against SOD1 ameliorate disease in mutant SOD1 transgenic mice

Mutations in Cu/Zn superoxide dismutase (SOD1) are the cause of ~20% of cases of familial ALS (FALS), which comprise ~10% of the overall total number of cases of ALS. Mutant (mt) SOD1 is thought to cause FALS through a gain and not loss in function, perhaps as a result of the mutant protein's misfol...

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Autori principali:	Ghanashyam D. Ghadge, Brian K. Kay, Claire Drigotas, Raymond P. Roos
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2019-01-01
Serie:	Neurobiology of Disease
Soggetti:	Familial amyotrophic lateral sclerosis Mutant superoxide dismutase type 1 Amyotrophic lateral sclerosis ALS Single chain fragments of variable region antibodies scFvs
Accesso online:	http://www.sciencedirect.com/science/article/pii/S0969996118305205
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