NRXN1 Deletion and Exposure to Methylmercury Increase Astrocyte Differentiation by Different Notch-Dependent Transcriptional Mechanisms

Controversial evidence points to a possible involvement of methylmercury (MeHg) in the etiopathogenesis of autism spectrum disorders (ASD). In the present study, we used human neuroepithelial stem cells from healthy donors and from an autistic patient bearing a bi-allelic deletion in the gene encodi...

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Principais autores:	Marilena Raciti, Jahan Salma, Stefan Spulber, Giulia Gaudenzi, Zahra Khalajzeyqami, Mirko Conti, Britt-Marie Anderlid, Anna Falk, Ola Hermanson, Sandra Ceccatelli
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Frontiers Media S.A. 2019-06-01
סדרה:	Frontiers in Genetics
נושאים:	neurotoxicity methylmercury (MeHg) NRXN1 bi-allelic deletion autism spectrum disorders astroglia notch signaling pathway
גישה מקוונת:	https://www.frontiersin.org/article/10.3389/fgene.2019.00593/full
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