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Application of machine learning combined with population pharmacokinetics to improve individual prediction of vancomycin clearance in simulated adult patients

Background and aim:Vancomycin, a glycopeptide antimicrobial drug. PPK has problems such as difficulty in accurately reflecting inter-individual differences, and the PPK model may not be accurate enough to predict individual pharmacokinetic parameters. Therefore, the aim of this study is to investiga...

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Principais autores: Guodong Li, Yubo Sun, Liping Zhu
פורמט: Artigo
שפה:Inglês
יצא לאור: Frontiers Media S.A. 2024-03-01
סדרה:Frontiers in Pharmacology
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גישה מקוונת:https://www.frontiersin.org/articles/10.3389/fphar.2024.1352113/full
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