A diverse repertoire of human immunoglobulin variable genes in a chicken B cell line is generated by both gene conversion and somatic hypermutation

Chicken immune responses to human proteins are often more robust than rodent responses because of the phylogenetic relationship between the different species. For discovery of a diverse panel of unique therapeutic antibody candidates, chickens therefore represent an attractive host for human-derive...

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Hlavní autoři:	Philip A. Leighton, Benjamin eSchusser, Henry eYi, Jacob eGlanville, William eHarriman
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2015-03-01
Edice:	Frontiers in Immunology
Témata:	Gene Conversion Antibody repertoire Deep sequencing somatic hypermutation human antibodies chicken B cells
On-line přístup:	http://journal.frontiersin.org/Journal/10.3389/fimmu.2015.00126/full
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