Genetic anticipation and cardiac conduction abnormalities in myotonic dystrophy type 1: implications for early stratification from a multicenter registry

Background: DM1 is an autosomal dominant disorder caused by unstable CTG repeats that expand over lifetime and in successive generations, contributing to genetic anticipation. Cardiac conduction abnormalities (CCAs) are a major source of morbidity and premature death in DM1, yet the influence of age...

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Detalhes bibliográficos

Principais autores:	Rebeca Lorca, Alberto Alen, Carlos Moliner-Abós, Fernando de Frutos, Néstor Báez-Ferrer, María Luisa Peña-Peña, Eduardo Villacorta, Tomas Ripoll-Vera, Esther Zorio, Aaron Martínez-Gimeno, José Bermúdez-Jiménez, Javier Limeres, Coloma Tiron, José M. Larrañaga-Moreira, Eva Cabrera-Romero, Pablo García-Pavía, María Angeles Espinosa, Jesús Piqueras, Soledad García-Hernández, Julián Palomino-Doza, Marc Soriano-Amores, German Moris, Lidia María Carrillo-Mora, Petros Syris, Rut Alvarez-Velasco, Juan Ramón Gimeno, Carmen Muñoz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2026-02-01
coleção:	International Journal of Cardiology: Heart & Vasculature
Assuntos:	Myotonic dystrophy type 1 (DM1) Inherited cardiac disease Cardiac conduction abnormalities (CCA) Sudden cardiac death (SCD) Cardiovascular genetics
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2352906725002544
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