Detection of extracellular amyloid beta aggregates by an Aducanumab-based synNotch receptor: an in vitro proof-of-concept study

Abstract Background Synthetic Notch (synNotch) receptors are a powerful gene regulation platform that activate transcription in response to membrane-bound ligands and extracellular matrix components, with emerging applications in cancer, autoimmunity, and regenerative medicine. Whether synNotch can...

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Principais autores:	Nicholas J. Bergo, Suckwon Lee, Cynthia J. Siebrand, Zachary Mayeri, Julie K. Andersen, Chaska C. Walton
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2025-11-01
Serija:	Journal of Translational Medicine
Teme:	Aducanumab Aduhelm Alzheimer’s disease Amyloid beta Cell-based drug delivery In vitro model
Online dostop:	https://doi.org/10.1186/s12967-025-07324-2
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