Inhibition of the succinyl dehydrogenase complex in acute myeloid leukemia leads to a lactate-fuelled respiratory metabolic vulnerability

Inhibition of specific metabolic pathways often drives metabolic adaptation. Here, the authors show that FLT3-ITD + acute myeloid leukemia cells are OXPHOS-driven, and inhibition of complex II activity results in increased lactate influx to drive respiration, which creates a targetable vulnerability...

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Detalhes bibliográficos

Principais autores:	Ayşegül Erdem, Silvia Marin, Diego A. Pereira-Martins, Marjan Geugien, Alan Cunningham, Maurien G. Pruis, Isabel Weinhäuser, Albert Gerding, Barbara M. Bakker, Albertus T. J. Wierenga, Eduardo M. Rego, Gerwin Huls, Marta Cascante, Jan Jacob Schuringa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2022-04-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-022-29639-0
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