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Intercellular cross-talk through lineage-specific gap junction of cancer-associated fibroblasts related to stromal fibrosis and prognosis

Abstract Stromal fibrosis in cancer is usually associated with poor prognosis and chemotherapy resistance. It is thought to be caused by fibroblasts; however, the exact mechanism is not yet well understood. The study aimed to identify lineage-specific cancer-associated fibroblast (CAF) subgroup and...

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Hauptverfasser: Seong Ju Cho, Ji-Hye Oh, Jaehoon Baek, Yunsu Shin, Wonkyung Kim, Junsu Ko, Eunsung Jun, Dakeun Lee, Seok-Hyung Kim, Insuk Sohn, Chang Ohk Sung
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2023-08-01
Schriftenreihe:Scientific Reports
Online-Zugang:https://doi.org/10.1038/s41598-023-40957-1
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