Priming astrocytes with TNF enhances their susceptibility to Trypanosoma cruzi infection and creates a self-sustaining inflammatory milieu

Abstract Background In conditions of immunosuppression, the central nervous sty 5ystem (CNS) is the main target tissue for the reactivation of infection by Trypanosoma cruzi, the causative agent of Chagas disease. In experimental T. cruzi infection, interferon gamma (IFNγ)+ microglial cells surround...

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Principais autores:	Andrea Alice Silva, Rafael Rodrigues Silva, Daniel Gibaldi, Rafael Meyer Mariante, Jessica Brandão dos Santos, Isabela Resende Pereira, Otacílio Cruz Moreira, Joseli Lannes-Vieira
Format:	Artigo
Jezik:	Inglês
Izdano:	BMC 2017-09-01
Serija:	Journal of Neuroinflammation
Teme:	Tumor necrosis factor Chagas disease Pentoxifylline Anti-TNF antibody Infliximab TNFR1
Online dostop:	http://link.springer.com/article/10.1186/s12974-017-0952-0
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