Systemic MCP-1 Levels Derive Mainly From Injured Liver and Are Associated With Complications in Cirrhosis

Background and Aims: Monocyte chemotactic protein-1 (MCP-1) is a potent chemoattractant for monocytes. It is involved in pathogenesis of several inflammatory diseases. Hepatic MCP-1 is a readout of macrophage activation. While inflammation is a major driver of liver disease progression, the origin a...

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Autors principals:	Alexander Queck, Hannah Bode, Frank E. Uschner, Maximilian J. Brol, Christiana Graf, Martin Schulz, Christian Jansen, Michael Praktiknjo, Robert Schierwagen, Sabine Klein, Christian Trautwein, Hermann E. Wasmuth, Marie-Luise Berres, Jonel Trebicka, Jennifer Lehmann
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2020-03-01
Col·lecció:	Frontiers in Immunology
Matèries:	acute-on-chronic liver failure (ACLF) decompensated liver cirrhosis inflammation monocyte chemotactic protein 1 (MCP-1) transjugular intrahepatic portosystemic shunt (TIPS)
Accés en línia:	https://www.frontiersin.org/article/10.3389/fimmu.2020.00354/full
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