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Runaway uncoupling in 2,4-dinitrophenol poisoning: Clinical and mitochondrial observations from two cases

2,4-Dinitrophenol (DNP) is a potent mitochondrial uncoupler briefly marketed in the 1930s as a weight-reducing agent before being banned by the FDA after reports of severe toxicity. Since the early 2000s, DNP has reemerged as an illicit “fat-burner”, causing characteristic metabolic disturbances wit...

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Principais autores: Erik Lindeman, Tine Sommer, Märta Leffler, Shusuke Sekine, Eskil Elmér, Fredrik Sjövall, Wilhelm Wallquist
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2026-06-01
Serier:Toxicology Reports
Fag:
DNP
Hyperthermia
Mitochondrial uncoupling
Postmortem redistribution
Online adgang:http://www.sciencedirect.com/science/article/pii/S2214750025003026
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