Bis-Indole Derivatives as Dual Nuclear Receptor 4A1 (NR4A1) and NR4A2 Ligands

Bis-indole derived compounds such as 1,1-bis(3′-indolyl)-1-(3,5-disubstitutedphenyl) methane (DIM-3,5) and the corresponding 4-hydroxyl analogs (DIM8-3,5) are NR4A1 ligands that act as inverse NR4A1 agonists and are potent inhibitors of tumor growth. The high potency of several DIM-3,5 analogs (IC<s...

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Principais autores:	Srijana Upadhyay, Amanuel Esayas Hailemariam, Fuada Mariyam, Zahin Hafiz, Gregory Martin, Jainish Kothari, Evan Farkas, Gargi Sivaram, Logan Bell, Ronald Tjalkens, Stephen Safe
Formato:	Artigo
Idioma:	Inglês
Publicado:	MDPI AG 2024-02-01
Series:	Biomolecules
Assuntos:	NR4A1 NR4A2 bis-indole dual binding
Acceso en liña:	https://www.mdpi.com/2218-273X/14/3/284
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