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Pancreatic tumors exhibit myeloid-driven amino acid stress and upregulate arginine biosynthesis

Nutrient stress in the tumor microenvironment requires cancer cells to adopt adaptive metabolic programs for survival and proliferation. Therefore, knowledge of microenvironmental nutrient levels and how cancer cells cope with such nutrition is critical to understand the metabolism underpinning canc...

Whakaahuatanga katoa

I tiakina i:
Ngā kaituhi matua: Juan J Apiz Saab, Lindsey N Dzierozynski, Patrick B Jonker, Roya AminiTabrizi, Hardik Shah, Rosa Elena Menjivar, Andrew J Scott, Zeribe C Nwosu, Zhou Zhu, Riona N Chen, Moses Oh, Colin Sheehan, Daniel R Wahl, Marina Pasca di Magliano, Costas A Lyssiotis, Kay F Macleod, Christopher R Weber, Alexander Muir
Hōputu: Artigo
Reo:Inglês
I whakaputaina: eLife Sciences Publications Ltd 2023-05-01
Rangatū:eLife
Ngā marau:
metabolism
tumor microenvironment
amino acid homeostasis
arginine
nutrient stress
Urunga tuihono:https://elifesciences.org/articles/81289
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