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Intranasal administration in modulating depressive-like behavior and reconstructing treatment paradigms through neuroinflammation and neurotrophic pathways

Abstract Intranasal administration, as a non-invasive brain-targeted delivery strategy, offers a promising approach for the treatment of central nervous system disorders, particularly depression. Traditional oral or intravenous drug delivery is often limited by the restrictive permeability of the bl...

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Principais autores: Juan An, Xuejing Li, Zhiqi Li, Jinghui Wang, Yuanming Pan
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2026-04-01
Serier:Journal of Nanobiotechnology
Fag:
Intranasal administration
Depression
Brain-targeted delivery
Nanocarriers
Neuroinflammation
Neuroplasticity
Online adgang:https://doi.org/10.1186/s12951-026-04417-y
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