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Nanotherapeutics Containing Lithocholic Acid-Based Amphiphilic Scorpion-Like Macromolecules Reduce In Vitro Inflammation in Macrophages: Implications for Atherosclerosis

Previously-designed amphiphilic scorpion-like macromolecule (AScM) nanoparticles (NPs) showed elevated potency to counteract oxidized low-density lipoprotein (oxLDL) uptake in atherosclerotic macrophages, but failed to ameliorate oxLDL-induced inflammation. We designed a new class of composite AScMs...

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Main Authors: Alysha Moretti, Qi Li, Rebecca Chmielowski, Laurie B. Joseph, Prabhas V. Moghe, Kathryn E. Uhrich
Format: Artigo
Language:Inglês
Published: MDPI AG 2018-02-01
Series:Nanomaterials
Subjects:
atherosclerosis
amphiphile
TGR5
lithocholic acid
nanoparticle
inflammation
macrophages
Online Access:http://www.mdpi.com/2079-4991/8/2/84
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