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Mechanisms of opening and closing of the bacterial replicative helicase

Assembly of bacterial ring-shaped hexameric replicative helicases on single-stranded (ss) DNA requires specialized loading factors. However, mechanisms implemented by these factors during opening and closing of the helicase, which enable and restrict access to an internal chamber, are not known. Her...

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Principais autores: Jillian Chase, Andrew Catalano, Alex J Noble, Edward T Eng, Paul DB Olinares, Kelly Molloy, Danaya Pakotiprapha, Martin Samuels, Brian Chait, Amedee des Georges, David Jeruzalmi
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2018-12-01
Serier:eLife
Fag:
DNA replication
DnaB replicative helicase
helicase loader
replication initiation
cryogenic electron microscopy
structural biology
Online adgang:https://elifesciences.org/articles/41140
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