Ancistrocladinium A Induces Apoptosis in Proteasome Inhibitor-Resistant Multiple Myeloma Cells: A Promising Therapeutic Agent Candidate

The <i>N</i>,<i>C</i>-coupled naphthylisoquinoline alkaloid ancistrocladinium A belongs to a novel class of natural products with potent antiprotozoal activity. Its effects on tumor cells, however, have not yet been explored. We demonstrate the antitumor activity of ancistrocladinium A in multiple m...

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Principais autores:	Daniela Brünnert, Raina Seupel, Pankaj Goyal, Matthias Bach, Heike Schraud, Stefanie Kirner, Eva Köster, Doris Feineis, Ralf C. Bargou, Andreas Schlosser, Gerhard Bringmann, Manik Chatterjee
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-08-01
Colecção:	Pharmaceuticals
Assuntos:	multiple myeloma ancistrocladinium A naphthylisoquinoline alkaloids proteasome inhibitor resistance RNA splicing cellular stress response
Acesso em linha:	https://www.mdpi.com/1424-8247/16/8/1181
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