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GRK Inhibition Potentiates Glucagon-Like Peptide-1 Action

The glucagon-like peptide-1 receptor (GLP-1R) is a G-protein-coupled receptor (GPCR) whose activation results in suppression of food intake and improvement of glucose metabolism. Several receptor interacting proteins regulate the signaling of GLP-1R such as G protein-coupled receptor kinases (GRK) a...

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Autori principali: Seunghun P. Lee, Jenson Qi, Guozhang Xu, Matthew M. Rankin, James Littrell, June Zhi Xu, Ivona Bakaj, Alessandro Pocai
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2021-05-01
Serie:Frontiers in Endocrinology
Soggetti:
GRK2 = G protein–coupled receptor kinase 2
GLP-1
diabetes
obesity
NASH
insulin secretion
Accesso online:https://www.frontiersin.org/articles/10.3389/fendo.2021.652628/full
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