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Gypenoside XLIX ameliorates diabetic retinopathy by downregulating prostaglandin-endoperoxide synthase 2 in retinal pigment epithelium cells to inhibit ferroptosis and preserve tight junction integrity

IntroductionDiabetic retinopathy (DR) represents a prevalent and severe eye complication in diabetic patients. With DR progresses, destruction of tight junctions (TJs) in RPE cells leads to irreversible visual impairment. Gypenoside XLIX (Gyp XLIX) is a dammarane-type glycoside, which can suppress i...

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Main Authors: Jiayi Gu, Manhui Zhu, Lele Li, Xin Cao, Xiaoli Yu, Xiaobo Huang, Lili Huang, Qi Cai, Yan Zhu, Wendie Li, Yong Wang
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2026-03-01
Series:Frontiers in Pharmacology
Subjects:
diabetic retinopathy
ferroptosis
gypenoside XLIX
networkpharmacology
prostaglandin-endoperoxide synthase 2
retinal pigment epithelium
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2026.1777313/full
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