Exosomal miR-202-5p derived from iPSC-MSCs protects against myocardial infarction through inhibition of cardiomyocyte pyroptosis

Abstract Background NOD-like receptor thermal protein domain associated protein 3 (NLRP3)-mediated pyroptosis of cardiomyocytes is a key contributor to the progression of myocardial infarction (MI). This study aimed to investigate whether exosomes derived from human induced pluripotent stem cell-der...

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Autors principals:	Jiaqi Chen, Xiaoting Liang, Qian Han, Haiwei He, Xinran Huang, Ying Shen, Jie Qiu, Fang Lin, Cong Mai, Ziqi Li, Kexin Ma, Bei Hu, Xin Li, Yuelin Zhang
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-06-01
Col·lecció:	Stem Cell Research & Therapy
Matèries:	Exosomes Induced pluripotent stem cell Mesenchymal stem cells Myocardial infarction Cardiomyocytes Pyroptosis
Accés en línia:	https://doi.org/10.1186/s13287-025-04390-7
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