The structure-selective endonucleases GEN1 and MUS81 mediate complementary functions in safeguarding the genome of proliferating B lymphocytes

During the development of humoral immunity, activated B lymphocytes undergo vigorous proliferative, transcriptional, metabolic, and DNA remodeling activities; hence, their genomes are constantly exposed to an onslaught of genotoxic agents and processes. Branched DNA intermediates generated during re...

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Prif Awduron:	Keith Conrad Fernandez, Laura Feeney, Ryan M Smolkin, Wei-Feng Yen, Allysia J Matthews, William Alread, John HJ Petrini, Jayanta Chaudhuri
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	eLife Sciences Publications Ltd 2022-10-01
Cyfres:	eLife
Pynciau:	B cell biology DNA recombination genome stability holliday junction structure-selective endonucleases
Mynediad Ar-lein:	https://elifesciences.org/articles/77073
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