CDK1 phosphorylates WRN at collapsed replication forks
End-resection of double strand DNA breaks is essential for pathway choice between non-homologous end-joining and homologous recombination. Here the authors show that phosphorylation of WRN helicase by CDK1 is essential for resection at replication-related breaks.
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| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
Nature Portfolio
2016-09-01
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| Reeks: | Nature Communications |
| Online toegang: | https://doi.org/10.1038/ncomms12880 |
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