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Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis

Abstract Background Cancer/testis (CT) antigens/genes are usually overexpressed in cancers and exhibit high immunogenicity, making them promising targets for immunotherapy and cancer vaccines. The role of serine protease PRSS56 in cancers remains unknown to date. Methods RNA sequencing studies were...

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Principais autores: Dandan Li, Lingyun Xia, Pan Huang, Zidi Wang, Qiwei Guo, Congcong Huang, Weidong Leng, Shanshan Qin
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2023-07-01
coleção:Cell & Bioscience
Assuntos:
Cancer/testis gene
DNA methylation
Serine protease
Tumor antigen
Acesso em linha:https://doi.org/10.1186/s13578-023-01060-0
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