Fenofibrate, but not ezetimibe, prevents fatty liver disease in mice lacking phosphatidylethanolamine N-methyltransferase

Mice lacking phosphatidylethanolamine N-methyltransferase (PEMT) are protected from high-fat diet (HFD)-induced obesity and insulin resistance. However, these mice develop severe nonalcoholic fatty liver disease (NAFLD) when fed the HFD, which is mainly due to inadequate secretion of VLDL particles....

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Principais autores:	Jelske N. van der Veen, Susanne Lingrell, Xia Gao, Abhijit Takawale, Zamaneh Kassiri, Dennis E. Vance, René L. Jacobs
Format:	Artigo
Jezik:	Inglês
Izdano:	Elsevier 2017-04-01
Serija:	Journal of Lipid Research
Teme:	nonalcoholic fatty liver disease phosphatidylcholine peroxisome proliferator-activated receptor-α fibric acids steatohepatitis liver fibrosis
Online dostop:	http://www.sciencedirect.com/science/article/pii/S002222752033844X
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