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Betacellulin-Induced α-Cell Proliferation Is Mediated by ErbB3 and ErbB4, and May Contribute to β-Cell Regeneration

Betacellulin (BTC), an epidermal growth factor family, is known to promote β-cell regeneration. Recently, pancreatic α-cells have been highlighted as a source of new β-cells. We investigated the effect of BTC on α-cells. Insulin+glucagon+ double stained bihormonal cell levels and pancreatic and duod...

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Autors principals: Young-Sun Lee, Gyun Jee Song, Hee-Sook Jun
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2021-01-01
Col·lecció:Frontiers in Cell and Developmental Biology
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Accés en línia:https://www.frontiersin.org/articles/10.3389/fcell.2020.605110/full
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