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The Role of the Transcription Factor Nuclear Factor-kappa B in Thyroid Autoimmunity and Cancer

Nuclear factor-kappa B (NF-κB) is a ubiquitous transcription factor that is involved in inflammatory and immune responses, as well as in regulation of expression of many other genes related to cell survival, proliferation, and differentiation. In mammals, NF-κB comprises five subunits that can bind...

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Principais autores: Cesidio Giuliani, Ines Bucci, Giorgio Napolitano
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2018-08-01
coleção:Frontiers in Endocrinology
Assuntos:
NF-κB
thyroid autoimmunity
thyroid cancer
transcription factors
gene regulation
major histocompatibility complex
Acesso em linha:https://www.frontiersin.org/article/10.3389/fendo.2018.00471/full
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