Selectively Targeting Leukemic MOLT-4 Cells by MTX-cIBR Conjugate: Mechanism of Action and Cellular Entry

The ICAM-1-derived cIBR peptide selectively binds to the I-domain of LFA-1, a receptor highly expressed on leukemia T cells; thus, the MTX-cIBR conjugate can be used to target methotrexate (MTX) to leukemic T cells and reduce its off-target toxicity. However, the uptake, biological mechanism, and se...

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Detalhes bibliográficos

Principais autores:	Sista Werdyani, Meagan E. Weldele, Enade P. Istyastono, Sofia M. Harjana, Adi Hermawansyah, Wariya Nirachonkul, Dewi K. Paramita, Teruna J. Siahaan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-06-01
coleção:	Life
Assuntos:	targeted delivery leukemic T cell MTX cIBR MTX-cIBR MOLT-4
Acesso em linha:	https://www.mdpi.com/2075-1729/16/6/981
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