Protein disulfide isomerase ERp57 protects early muscle denervation in experimental ALS

Abstract Amyotrophic lateral sclerosis (ALS) is a progressive fatal neurodegenerative disease that affects motoneurons. Mutations in superoxide dismutase 1 (SOD1) have been described as a causative genetic factor for ALS. Mice overexpressing ALS-linked mutant SOD1 develop ALS symptoms accompanied by...

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Bibliografiske detaljer

Principais autores:	Pablo Rozas, Cristina Pinto, Francisca Martínez Traub, Rodrigo Díaz, Viviana Pérez, Daniela Becerra, Patricia Ojeda, Jorge Ojeda, Madison T. Wright, Jessica Mella, Lars Plate, Juan Pablo Henríquez, Claudio Hetz, Danilo B. Medinas
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2021-02-01
Serier:	Acta Neuropathologica Communications
Fag:	Amyotrophic lateral sclerosis Mutant SOD1 ERp57 Protein aggregation Neuromuscular junction
Online adgang:	https://doi.org/10.1186/s40478-020-01116-z
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