Protein Kinase CK1α Sustains B-Cell Receptor Signaling in Mantle Cell Lymphoma

Mantle Cell Lymphoma (MCL) is still an incurable B-cell malignancy characterized by poor prognosis and frequent relapses. B Cell Receptor (BCR) signaling inhibitors, in particular of the kinases BTK and PI3Kγ/δ, have demonstrated clinically meaningful anti-proliferative effects in B cell tumors. How...

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Autores principales:	Sabrina Manni, Anna Fregnani, Laura Quotti Tubi, Zaira Spinello, Marco Carraro, Greta Scapinello, Andrea Visentin, Gregorio Barilà, Marco Pizzi, Angelo Paolo Dei Tos, Fabrizio Vianello, Renato Zambello, Carmela Gurrieri, Gianpietro Semenzato, Livio Trentin, Francesco Piazza
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Frontiers Media S.A. 2021-10-01
Colección:	Frontiers in Oncology
Materias:	mantle cell lymphoma CK1α BCR inhibitors ibrutinib duvelisib targeted therapy
Acceso en línea:	https://www.frontiersin.org/articles/10.3389/fonc.2021.733848/full
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