Enhanced synaptotagmin plasticity derived from pairing intrinsic disorder with synaptic vesicle lipids

Synaptotagmin 1 (Syt 1) is an integral membrane protein responsible for sensing the calcium ion (Ca2+) influx in neurons that triggers synaptic vesicle exocytosis. How Syt 1's intrinsically disordered region (IDR), a ∼60 residue sequence located between the protein's transmembrane helix and two Ca2+...

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Bibliografische Detailangaben

Hauptverfasser:	Michael E. Fealey, David D. Thomas, Anne Hinderliter
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2017-07-01
Schriftenreihe:	Communicative & Integrative Biology
Schlagworte:	allostery lipids intrinsically disordered region synaptic vesicle synaptotagmin
Online-Zugang:	http://dx.doi.org/10.1080/19420889.2017.1343772
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